EFEKTIVITAS BUNGA TELANG (CLITORIA TERNATEA) TERHADAP RESPON GLIKEMIK: SISTEMATIK REVIEW
EFFECTIVNESS OF BUTTERFLY PEA FLOWER (CLITORIA TERNATEA) ON GLICHEMIC RESPONS: SYSTEMATIC REVIEW
DOI:
https://doi.org/10.52236/ih.v12i1.526Keywords:
Clitoria Ternatea, Blood Glucose Levels, Diabetes MellitusAbstract
Background: Diabetes mellitus is a chronic disease that is globally prevalent and has reached a very high prevalence rate. In 2021, more than 422 million people worldwide will suffer from diabetes. Various databases have reported that one of the ornamental plants, namely the butterfly pea flower (Clitoria Ternatea), has quite a hypoglycemic effect. Purpose: The aim of this systematic research is to help in understanding the potential of butterfly pea flowers as an antidiabetic agent. Methods: The research method we used in this systematic review search was the PRISMA method. This article searches literature sources in Pubmed and Google Scholar databases from 2013 to 2023 using appropriate inclusion criteria. Clitoria Ternatea has excellent anti-diabetic properties. Result: In vitro analysis showed that water extract of butterfly pea flower (Clitoria Ternatea), ethanol extract, and protein extract effectively inhibited the α-amylase enzyme, hemoglobin glycosylation, and AGE formation. They also show increased glucose absorption. Conclusion: This explains that CTE can suppress postprandial glucose and insulin responses induced by sucrose through inhibiting intestinal sucrose. It can be concluded that butterfly pea flowers (Clitoria Ternatea) are effective against glycemic responses in the body.References
Chusak, C. et al. (2018) ‘Acute effect of Clitoria ternatea flower beverage on glycemic response and antioxidant capacity in healthy subjects: A randomized crossover trial’, BMC Complementary and Alternative Medicine, 18(1), pp. 1–11. Available at: https://doi.org/10.1186/s12906-017-2075-7.
Daisy, P. and Rajathi, M. (2009) ‘Hypoglycemic effects of Clitoria ternatea Linn. (Fabaceae) in alloxan-induced diabetes in rats’, Tropical Journal of Pharmaceutical Research, 8(5), pp. 393–398. Available at: https://doi.org/10.4314/tjpr.v8i5.48082.
Gunawan, O. et al. (2023) ‘The Effect of Butterfly Pea Extract on Blood Glucose Levels in White Rats with Metabolic Syndrome Model’, Smart Medical Journal, 6(1), p. 14. Available at: https://doi.org/10.13057/smj.v6i1.67934.
Mathada V Ravishankar and Praful S Jevoor (2013) ‘Effect of Individual and Combination of Herbal Extracts on Glucose Tolerance , in Euglycemic Rats’, International Journal of Life Science Biotechnology and Pharma Research [Preprint].
Mobasher, M.A. et al. (2023) ‘Clitoria ternatea extract-loaded chitosan nanoparticles ameliorate diabetes and oxidative stress in diabetic rats’, Indian Journal of Biochemistry and Biophysics, 60(7), pp. 501–515. Available at: https://doi.org/10.56042/ijbb.v60i7.4140.
Ni Kadek Wewin Rasmeiyanti, Adi Sucipto, N.H.R. (2019) ‘Telang Tea Effective Reduce Levels Blood Sugar in Eldery’, pp. 45–49.
Pangondian, A. et al. (2023) ‘POTENSI EKSTRAK BUNGA TELANG (Clitorea ternatea L.) TERHADAP ANTIDIABETES PADA MENCIT PUTIH JANTAN (Mus musculus)’, Forte Journal, 3(2), pp. 150–157. Available at: https://doi.org/10.51771/fj.v3i2.630.
Putri, T.F., Wasita, B. and Indarto, D. (2023) ‘Administrations of Butterfly Pea Flower (Clitoria Ternatea L) Extract Reduce Oxidative Stress and Increase Body Weight of Male Wistar Rats with Diabetes’, Amerta Nutrition, 7(3), pp. 400–405. Available at: https://doi.org/10.20473/amnt.v7i3.2023.400-405.
Rajamanickam, M., Kalaivanan, P. and Sivagnanam, I. (2015) ‘Evaluation of anti-oxidant and anti-diabetic activity of flower extract of Clitoria ternatea L’, Journal of Applied Pharmaceutical Science, 5(8), pp. 131–138. Available at: https://doi.org/10.7324/JAPS.2015.50820.
Simangunsong, E.M.V. et al. (2023) ‘Effectiveness of Butterfly Pea Ethanol Extract on Decreasing Blood Glucose Levels of Male Mice’, Jambura Journal of Health Sciences and Research, 5(2), pp. 707–721. Available at: https://doi.org/10.35971/jjhsr.v5i2.18789.
Valentine, V. et al. (2019) ‘Administration of Butterfly Pea (Clitoria ternatea) Flower Etanol Extract Oral Increased the Number of Pancreatic Beta Cells and Decrease the Level of Glycated Hemoglobin (HbA1C) of Diabetic Male Wistar Rats (Rattus norvegicus)’, International Journal of Science and Research, 10(1), pp. 2319–7064. Available at: https://doi.org/10.21275/SR21126085109.
Widowati, W. et al. (2023) ‘Butterfly pea flower (Clitoria ternatea L.) extract displayed antidiabetic effect through antioxidant, anti-inflammatory, lower hepatic GSK-3β, and pancreatic glycogen on Diabetes Mellitus and dyslipidemia rat’, Journal of King Saud University - Science, 35(4), p. 102579. Available at: https://doi.org/10.1016/j.jksus.2023.102579.
Daisy, P. and Rajathi, M. (2009) ‘Hypoglycemic effects of Clitoria ternatea Linn. (Fabaceae) in alloxan-induced diabetes in rats’, Tropical Journal of Pharmaceutical Research, 8(5), pp. 393–398. Available at: https://doi.org/10.4314/tjpr.v8i5.48082.
Gunawan, O. et al. (2023) ‘The Effect of Butterfly Pea Extract on Blood Glucose Levels in White Rats with Metabolic Syndrome Model’, Smart Medical Journal, 6(1), p. 14. Available at: https://doi.org/10.13057/smj.v6i1.67934.
Mathada V Ravishankar and Praful S Jevoor (2013) ‘Effect of Individual and Combination of Herbal Extracts on Glucose Tolerance , in Euglycemic Rats’, International Journal of Life Science Biotechnology and Pharma Research [Preprint].
Mobasher, M.A. et al. (2023) ‘Clitoria ternatea extract-loaded chitosan nanoparticles ameliorate diabetes and oxidative stress in diabetic rats’, Indian Journal of Biochemistry and Biophysics, 60(7), pp. 501–515. Available at: https://doi.org/10.56042/ijbb.v60i7.4140.
Ni Kadek Wewin Rasmeiyanti, Adi Sucipto, N.H.R. (2019) ‘Telang Tea Effective Reduce Levels Blood Sugar in Eldery’, pp. 45–49.
Pangondian, A. et al. (2023) ‘POTENSI EKSTRAK BUNGA TELANG (Clitorea ternatea L.) TERHADAP ANTIDIABETES PADA MENCIT PUTIH JANTAN (Mus musculus)’, Forte Journal, 3(2), pp. 150–157. Available at: https://doi.org/10.51771/fj.v3i2.630.
Putri, T.F., Wasita, B. and Indarto, D. (2023) ‘Administrations of Butterfly Pea Flower (Clitoria Ternatea L) Extract Reduce Oxidative Stress and Increase Body Weight of Male Wistar Rats with Diabetes’, Amerta Nutrition, 7(3), pp. 400–405. Available at: https://doi.org/10.20473/amnt.v7i3.2023.400-405.
Rajamanickam, M., Kalaivanan, P. and Sivagnanam, I. (2015) ‘Evaluation of anti-oxidant and anti-diabetic activity of flower extract of Clitoria ternatea L’, Journal of Applied Pharmaceutical Science, 5(8), pp. 131–138. Available at: https://doi.org/10.7324/JAPS.2015.50820.
Simangunsong, E.M.V. et al. (2023) ‘Effectiveness of Butterfly Pea Ethanol Extract on Decreasing Blood Glucose Levels of Male Mice’, Jambura Journal of Health Sciences and Research, 5(2), pp. 707–721. Available at: https://doi.org/10.35971/jjhsr.v5i2.18789.
Valentine, V. et al. (2019) ‘Administration of Butterfly Pea (Clitoria ternatea) Flower Etanol Extract Oral Increased the Number of Pancreatic Beta Cells and Decrease the Level of Glycated Hemoglobin (HbA1C) of Diabetic Male Wistar Rats (Rattus norvegicus)’, International Journal of Science and Research, 10(1), pp. 2319–7064. Available at: https://doi.org/10.21275/SR21126085109.
Widowati, W. et al. (2023) ‘Butterfly pea flower (Clitoria ternatea L.) extract displayed antidiabetic effect through antioxidant, anti-inflammatory, lower hepatic GSK-3β, and pancreatic glycogen on Diabetes Mellitus and dyslipidemia rat’, Journal of King Saud University - Science, 35(4), p. 102579. Available at: https://doi.org/10.1016/j.jksus.2023.102579.
Additional Files
Published
2024-01-25
How to Cite
Nadhira, R., Natasya, A. ., Hendrawati, A., Audyta, R., Octaviani, T., Nurul Aini, Y. ., … Diding Kelana Setiadi. (2024). EFEKTIVITAS BUNGA TELANG (CLITORIA TERNATEA) TERHADAP RESPON GLIKEMIK: SISTEMATIK REVIEW: EFFECTIVNESS OF BUTTERFLY PEA FLOWER (CLITORIA TERNATEA) ON GLICHEMIC RESPONS: SYSTEMATIC REVIEW. Intan Husada : Jurnal Ilmiah Keperawatan, 12(01), 158–179. https://doi.org/10.52236/ih.v12i1.526
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